Nanostructured Surfaces for Antibiofouling Applications: Experimental Investigations and Model Analysis

Biofouling, the undesirable adhesion and accumulation of proteins, poses a persistent challenge in microfluidic devices used for assays in life sciences and related applications. This research explores the potential of nanostructured surfaces to mitigate biofouling by minimizing the contact area. A combination of experimental techniques and theoretical modeling will be employed to investigate how nanoscale topographies influence biofouling mechanisms. Key factors such as surface coating, adsorption time, protein concentration, and electrostatic forces will be examined to understand their interplay. The findings aim to provide valuable insights for designing surfaces with enhanced antibiofouling performance across various applications.