Modeling drug toxicity using sensor integrated microphyisological systems

Drug toxicity is a major challenge in drug development, often leading to late-stage failures in clinical trials. Traditional in vitro and animal models frequently fail to predict human-specific toxicities, underscoring the need for more advanced and reliable platforms. Sensor-integrated microphysiological systems (MPS), also known as organ-on-a-chip devices, offer a promising alternative by mimicking human tissues at a micro scale. These systems integrate tissue-engineered constructs with real-time monitoring through embedded sensors, allowing for dynamic assessment of physiological responses to drugs. The systems will be used to assess multi-organ drug toxicity using the sensors platform developed at imec, including TEER sensors, bioanalytical sensors and metabolic sensors.