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Ion channel measurement on epithelial barriers using HD-MEA
Leuven | More than two weeks ago
Discover how high density multielectrode array chips can be used to perform ion channel measurements in epithelial barriers for organ-on-chip applications.
Human in vitro models offer great potential for disease modeling and safety screening of drug candidates. Stem-cell based human cells represent a breakthrough to model human response, but proper maturation and differentiation to adult cell types hampers their relevance for human modeling. Besides this, cell culture models are often very heterogeneous in nature, which complicates further use and interpretation. Epithelial cells can be grown in vitro by using (patient-derived) stem cells to form proper tissue barriers. To map their response to drugs, typically, transepithelial electrical resistance is measured in static conditions. Despite the vast use of these methods, the lack of physiological environments such as microfluidic flow and the inability to dissect the response at the single cell level. Multielectrode arrays can offer resolution at this level, and moreover, are sensitive enough to detect ionic currents. This project goes beyond the state of the art by exploring novel ways of cellular heterogeneity in in vitro human models.
Required background: biomedical engineering, electrical engineering
Type of work: experimental 70%, modeling 20%, literature 10%
Supervisor: Liesbet Lagae
Co-supervisor: Dries Braeken
Daily advisor: Dries Braeken
The reference code for this position is 2025-122. Mention this reference code on your application form.